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NEW PRODUCT ALERT! Bremelanotide (PT-141) Injections

PT-141, also known as Bremelanotide, is a synthetic peptide that is used to treat sexual dysfunction in men and women. While Viagra and Cialis, which are PDE-5 inhibitors that work to increase blood flow into the penis, PT-141 is a melanocortin, which works in the brain to increase sexual desire. The synthetic peptide was developed from Melanotan II, and was originally intended to darken skin pigmentation and induce tanning. However, during the initial testing, patients noted a pleasant side effect – that it caused increased sexual arousal.

How Does Bremelanotide PT-141 Work?

Bremelanotide PT-141 is a molecule that binds to and activates the melanocortin receptors associated with skin pigmentation. Once injected, PT 141 binds to melanocortin receptors (MC3-R and MC4-R) in the brain's hypothalamus. Brain neurons activate resulting enhancement in libido.

Currently, Bremelanotide PT-141 is administered via a subcutaneous injection, ideally where there are fat deposits. The only legitimate form of the peptide is injectable. Oral pills, nasal sprays, and creams have not been shown to be an effective means in which to administer Bremelanotide PT-141.

Bremelanotide is FDA approved to treat hypoactive sexual desire disorder (HSDD) in premenopausal women who previously had no problems with sexual desire and that occurs in any type of stimulation, situation, or partner. It should only be used in women who have low sexual desire that is troubling to them and is not caused by a medical or mental health problem, problems in the relationship, or medicine or other drug use.

Dosing - 1 milligram (mg) injected under the skin at least 1 hour before a sexual activity. Do not use more than one dose of this medicine within 24 hours. Do not use more than 8 doses per month.

Pricing- sold in packages of 4(four) 1mg pre-filled syringes for subcutaneous administration for $30.00.

We will provide training for simple self-administration at home.

Medication must be refrigerated.

Keep out of the reach of children.

Drug Interactions - Naltrexone

Medical Problems:

This peptide is not to be used if a personal history or family history of Melanoma.

  • Heart or blood vessel disease or uncontrolled hypertension ( Your heart needs to be in good enough shape to have sex)

  • Kidney disease, severe or Liver disease, severe—Use with caution. The effects may be increased because of the slower removal of the medicine from the body.

  • Stomach or bowel problem (eg, slow gastric emptying)—Use with caution. May make this condition worse and decrease the absorption of oral medicines.

  • Breastfeeding-There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

  • Pregnancy- Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine. If you think you have become pregnant while using this medicine, tell your doctor right away.

Potential Side Effects - Nausea may occur after first using bremelanotide, which may last for 2 hours or more. Your doctor may give you an anti-emetic medicine for this. Check with your doctor right away if the nausea is severe or continuing.

This medicine may cause darkening of the skin on the face, gums, or breasts, especially in patients with darker skin and daily use. Talk to your doctor if you have concerns about any skin changes.

Rare Side Effects - Blurred vision, dizziness, Headache, nervousness

Additional Scientific Data on PT-141

PT-141 is a synthetic peptide analog of alpha melanocyte-stimulating hormone (α-MSH), an endogenous neuropeptide best known for its role in stimulating melanogenesis, or the production of melanin.

A non-selective agonist of the melanocortin receptors, PT-141 binds notably to the melanocortin 3 and 4 receptors (MC3R, MC4R), which link to the modulation of sexual behavior and appetite.

In fact, extensive clinical research has shown that PT-141′s activity at MC3R and MC4R increases sexual desire in women with hypoactive sexual desire disorder (HSDD), a fairly common disorder that is characterized by a low or lack of sex drive in women.

In the United States, PT-141 has been assigned the generic name “bremelanotide,” and is prescribed to HSDD patients as Vyleesi, a prefilled autoinjector pen that is self-administered by the patient.

What Does PT-141 Do?

As a melanocortin receptor agonist, PT-141 initiates a physiological response in the subject upon making contact with the melanocortin receptors, located primarily in the midbrain. Both melanocortin receptors 3 and 4 are believed to play a key role in sexual desire and arousal in both males and females.

PT-141 is believed to stimulate dopamine hormones that are linked to increased sexual desire; in men, this results in penile erection [6]. This mechanism may be considered advantageous to that of traditional erectile dysfunction (ED) treatments, such as Viagra, which are vasodilators that directly increase blood flow to the penis but require sexual arousal and stimulation to take effect.

In the case of women, PT-141 is also thought to work primarily through its activity at MC3R and MC4R, thus triggering the release of dopamine and increasing sexual desire. Prior to the clinical use of PT-141 in women, the treatment of HSDD often included psychosocial and biological treatments, requiring consistent daily or weekly treatments. Fortunately, PT-141 can be taken on an as-needed basis, approximately 60 minutes prior to sexual activity via subcutaneous injection.

Are you interested in this new product? Give our office a call today 334-209-1061!


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